Lyostat5 fromBiopharma Technology Ltd (BTL) is an advanced freeze drying microscope, with PC control for image and data capture and analysis functions.Freeze drying microscopy (FDM) was established in the 1960s as a technique for identifying critical formulation parameters and is the only method for reliably determining collapse temperatures. Historically FDM was used only for collapse / eutectic temperatures but the latest generation FDM can also enables identification of crystallization phenomena, the potential for skin/crust formation, and the effects of annealing on ice crystal growth and solute structure.
Lyostat analysis uses just 2µl and is typically complete in under an hour. Lyostat is supplied fully validated as a complete working system against a series of standard solutions . Lyostat is PC controlled to provide sophisticated image and data capture and analysis functions, which also allows the user to make a video of their sample under analysis. The software is also available in a 21CFR11 compliant version.
BTL has expertise in the formulation of products, accounting for the lyophilisation(freeze drying) steps involved in the development and/or production process. To date BTL has worked with over 1800 products, from small molecules to proteins, organisms, whole cells , collagen products, blood and archaeological samples.