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LC/MS/MS Rapid Toxicology Screening System

Predetermined Analytical Conditions

This system provides MRM transitions, LC separation conditions, retention times, spectral libraries, and report files, enabling rapid implementation of a screening method for many important toxicological substances.

Screening for 161 Compounds

Developed in conjunction with front-line researchers in the toxicology field, the method analyzes several classes of substances. LCMS MRM optimization has been performed for common drugs of abuse, hypnotics, psychotropics, pharmaceuticals and other natural toxins. Shimadzu’s Ultra-Fast MS technology enables triggered product ion scans, which provide MS/MS data during MRM acquisition.

Semi-Quantitative Results without Authentic Standards

By incorporating established calibration curves, this screening system provides laboratories the ability to perform semi-quantitative analysis without purchasing dozens of costly standards.

Also included is an optimized sample preparation protocol for toxicology screening based on QuEChERS*. From sample preparation to reporting, a total solution for toxicology screening is provided.

* QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) was developed by Anastassiades et al in 2003 as a sample preparation method for residual pesticide analysis in agricultural products.
LC/MS/MS Rapid Toxicology Screening System
HPLC Conditions
  • Analytical Column : Kinetex XB-C18 (2.1 mmI.D. × 100 mmL., 2.6 μm) (Phenomenex)
  • Guard Column : SecurityGuard Ultra C18 2.1mmID (Phenomenex)
  • Mobile phase A : 10 mmol/L Ammonium formate + 0.1 % Formic acid in Water
  • Mobile phase B : 10 mmol/L Ammonium formate + 0.1 % Formic acid in Methanol
  • Flow rate : 0.3 mL/min
  • Injection volume : 5 μL
StepTime (min)A (%)B (%)
00955
17.5595
210595
310.01955
415955

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