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LCMS-8050 Liquid Chromatograph – Mass Spectrometer

Shimadzu’s LCMS-8050 offers unparalleled measurement speeds and high-sensitivity performance, redefining LC-MS/MS analysis for multi-component quantitation, reliable qualitative analysis etc. A whole new set of UF Technologies combining sensitivity and speed has been built into the LCMS-8050 to meet the emerging challenges.

The LCMS-8050 combines the following technologies to ensure highly sensitive, high-speed performance:

UfsensitivityTM achieves high-sensitivity performance utilizing a new heated ESI probe and newUFsweeper III collision cell.

UFswitchingTM high-speed positive/negative ionization switching and high-speed MRM [UF-MRM] maintain data quality and sensitivity.

UFscanningTM high-speed scan rate obtains high-quality mass spectra, even during high-speed analysis.

The LCMS-8050 is capable of simultaneously obtaining both qualitative and quantitative information in a single analysis. Acquisition occurs so rapidly that MS/MS scans and MRM measurements can be performed concurrently while maintaining quantitative accuracy. MS/MS scans are usable and reliable because even at 30,000 u/sec, Shimadzu uses a 0.1 u scan step. The LCMS-8050 is the only instrument of its class to achieve positive/negative ionization switching time of just 5msec for stable quantitative accuracy.The LCMS-8050 is capable of simultaneously acquiring 555 MRM transitions per second while maintaining accuracy and precision which helps in detection of target compounds at trace-level concentrations.

A variety of method packages, which include pre-registered MRM parameters with optimized quantitative and reference ions, LC separation parameters, retention times, and peak identification parameters for various compounds, enable efficient implementation of simultaneous multi-component analyses. Method Packages include: Primary Metabolites (55 metabolites), Lipid mediators (130 lipid mediators), Rapid Toxicological Drug Screening (106 drugs), Forensic & Toxicology (286 toxic substances), Residual Pesticides (167 pesticides), Veterinary Drugs(42 drugs), Water Quality analysis (44 golf course pesticides), Cell Culture profiling (85 compounds) etc.

  • UFsensitivity - Combining Speed and Sensitivity
  • UFswitching- Polarity switching of 5 msec
  • UFscanning – 30,000 u/sec high speed scanning
  • UF-MRM – 555 ch/sec for targeted analysis
  • Outstanding throughput and quantitative accuracy
  • Ease of Maintenance
  • Wide Choice of Method Packages
APPI Interface
LCMS-8050 Brochure

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