By incorporating improved ion optics UF-LensTM and UfsweeperTM collision cell technology, the LCMS-8040 provides higher multiple reaction monitoring (MRM) sensitivity. A five-fold increase in sensitivity (reserpine, S/N ratio) has been achieved over the previous models by improving ion focussing and minimizing ion losses between multiple-pole lenses. These improvements also yield higher sensitivity for scan mode measurements.
The LCMS -8040 has been designed to provide significantly higher sensitivity while maintaining the high speed offered by the LCMS-8030. Ultrafast MRM transition speeds, upto 555 MRMs per second (dwell times of 1msec and pause times of 1 msec) are easily achieved. In addition, the LCMS-8040 features the world’s fastest polarity switching at 15 msec and high speed scanning rate of 15,000 u/sec.
Multiple compounds can be optimized in an unattended sequence, freeing the analyst from tedious work. MRM parameters optimized for the LCMS-8030 can be transferred to the LCMS-8030 can be easily transferred to the LCMS-8040, making it possible to transfer methods between two systems. The LCMS-8040 offers the same ease of maintenance benefits as the LCMS-8030 and all consumables, such as desolvation lines (DL) and ESI capillaries, are interchangeable well.
MRM parameters can be easily set up in LCM-8040 with a rapid and simplified approach based on automated flow injection analysis, an optimization function included LabSolutions that allows anyone to optimize parameters easily. Optimization choices include voltages for Q1 pre-rod, Q3 pre-rod, and Collision Energy. MRM transitions are determined by selecting the product ions with the highest abundance.
Several method packages , which contain chromatographic and optimized MRM conditions for a variety of analytes, have been released. Method packages enable “Ready-to-Use” methods , including pre-registered MRM parameters with optimized quantitative and reference ions, LC separation parameters, and retention times and peak identification parameters for ‘cell culture profiling’, ‘toxicology screening’, ‘residual pesticides’, ‘ veterinary drugs’, ‘drugs of abuse’ , ‘water quality analysis’ etc.