AXIMA Confidence MALDI TOF-TOF Mass Spectrometer

The AximaConfidence™ is designed with the general analytical and life science laboratory in mind. Incorporating a variable repetition rate 50Hz N2 laser, the system provides rapid, high quality MALDI mass spectra and an array of software tools for data processing and reporting.

Linear mode allows the integration of high molecular weight samples, whilst reflectron mode, incorporating the patented curved-field reflectron (CFR) provides the high resolution and mass accuracy necessary for successful proteomics and life science experiments. Positive and negative ions are included as standard allowing greater flexibility . The patented beam blanker optionally removes unwanted low mass ions and prevents detector saturation.

• Near-axis laser irradiation with a 50Hz variable repetition rate N2 laser
• Patented improved curved field reflectron
• Mass range 1-500kDa in linear mode; 1-80kDa in reflectron mode
• Mass resolution 5000 FWHM (ACTH 18-39) in linear mode; 15000 FWHM (ACTH 7-38) in reflectron mode
• Sensitivity 500 amol (Glu-fibrinopeptide) in reflectron mode
• Mass accuracy <10ppm in reflectron mode with internal calibration
• Precursor ion resolution >200 FWHM
• Seamless MS/MS utilising PSD
• Flexible target formats - ranging from 48 well microscope slide format targets to 384 well microtitre plate targets

Excellent sensitivity is achieved using near normal (on-axis) laser irradiation and advanced ion optics for enhanced ion transmission. MS/MS may be easily performed using a seamless approach-ions of interest can be isolated using a precursor ion selection device and data-rich fragment ion spectra quickly and simply acquired . The system supports standard microtitre plate format 96 or 384 well targets.

Fleximass™ microscope slide (plain or 48 well targets) and a wide variety of adapters for unconventional samples, are also available.

Launchpad™ suite of software permits manual or automatic operations facilitating seamless analysis. The AximaConfidence™ is ideally suited for applications such as

• Proteomics experiments
• LC MALDI
• Polymer analysis
• Tissue imaging/biomarker discovery
• Oligonucleotide/primer analysis

Application-centric data processing software packages - PolymerAnalysis™, OligoAnalysis™, provide solutions to many common analysis requirements. Intellimarque™ has been uniquely designed for proteomics experiments with a flexibility to user workflows involving data-dependent peptide mass fingerprinting and MS/MS for protein identification .

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