Nexera-e Comprehensive Two-Dimensional Liquid Chromatograph

Comprehensive 2D-LC methodology is a paradigm shift in liquid chromatography separation analysis. By combining two independent separation modes orthogonally in combination with a dual-loop/dual-valve alternate switching design, the highest possible peak capacity is achieved for LC chromatography separation. The new Nexera-e enables separation of even the most complex mixtures, providing a new level of knowledge and understanding of sample analytes. This is especially beneficial to the analysis of pharmaceutical impurities, proteolytic digests, food extracts, natural products and synthetic polymers.

Comprehensive 2D-LC fractionates the 1^st-dimensional eluent and successively separates the fraction on-line with the 2^nd-dimensional system. Therefore, the 1^st-dimensional system intersects with the 2^nd-dimensional system at the dual valves and dual-loops. With valve switching, these loops continue the fractionation of the eluent from the 1^st-dimensional system and the injection of the fraction to the 2^nd-dimensional system alternately.

• New Paradigm in liquid chromatography
• Two orthogonal systems for comprehensive 2D separation
• Powerful ChromSquare* Software for Qualitative & Quantitative Analysis
• Ultra Fast Mass Spectrometry for advanced detection
• Provides new levels of knowledge & understanding on analytes

*ChromSquare is a product of Chromaleont S.r.l., Italy.

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