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DynaPro® Plate Reader III High-Throughput Dynamic Light Scattering Detector

The new DynaPro Plate Reader III excels at high-throughput sizing and screening of pharmaceutical and nanoparticle formulations to enable novel workflows that simply would not be possible with other DLS measurements. The system provides unique solutions for biopharmaceutical development through measurements of aggregation, aggregate size distributions, changes in solution molecular weight and propensity for aggregation; indicators of both thermal stability (Tonset,Tm, Tagg) and colloidal stability (A2/B22,kD) may be quantified with plate-based Dyamic Light Scattering as well as Static Light Scattering (SLS). This ground-breaking instrument provides rapid optimization of the formulation process for:

  • Biotherapeutics such as monoclonal antibodies and virus-like particles (VLPs)
  • Nanoparticle drug delivery vehicles including liposomes and conjugated gold NPs
  • Polymer-encapsulated drug particles

The DynaPro Plate Reader III provides unparalleled levels of ease-of-use, productivity, reproducibility, and flexibility in order to address additional demanding applications such as:

  • Optimizing protein crystallization
  • Assessing aggregation or oligomerization
  • Determining protein stability-indicating parameters such as thermal denaturation and colloidal stability
  • Screening high-concentration protein solutions for reversible association and viscosity
Key Features
  • Measure hydrodynamic radius from 0.5 nm to 1000 nm
  • Sensitivity for size down to 0.125 mg/mL lysozyme
  • Measure weight-average molar mass from 1 to 1000 kDa
  • Industry standard microwell plates of 96, 384 or 1536 wells
  • Sample volume from 4 μL to 150 μL
  • All measurements made in situ in the wells
  • Temperature ramps from 4°C to 85°C
  • Integrates with plate-based liquid handling robotics
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