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Sequel System: High-Throughput, Cost-Effective Access to SMRT Sequencing

The new Sequel System is based on PacBio’s proven Single Molecule, Real-Time (SMRT) technology and delivers about 7X more reads with 1 million zero-mode waveguides (ZMWs) per SMRT Cell. SMRT® technology is built upon two key innovations that overcome major challenges in the field of sequencing. Zero Mode Waveguides(ZMW) allow light to illuminate only the bottom of a well in which a DNA polymerase/template complex is immobilized. Phospholinked nucleotides allow observation of the immobilized complex as the DNA polymerase produces a completely natural DNA strand. The Sequel System is ideal for projects such as rapidly and cost-effectively generating high-quality whole genome de novo assemblies.

The innovative sequencing system features automated reagent and SMRT Cell handling and an integrated software suite. Additional features of the Sequel System include: Intuitive run setup and monitoring tools; Run-time flexibility (from 30 minutes to 10 hours per SMRT Cell); Run-size flexibility (from 1 to 16 SMRT Cells per run); Robotic workflow management

SMRT Sequencing gives a number of advantages:

  • Long Read Lengths
  • High Consensus Accuracy
  • Uniform Coverage
  • Simultaneous Epigentic Characterization

Gain a Comprehensive View of Genomics, Transcriptomes and Epigenomes

  • Create high-quality whole genome de novo assemblies of eukaryotic organisms
  • Survey large population cohorts and resolve structural variants
  • Read full-length transcripts to characterize isoform diversity
  • Target all variant types across relevant genomic regions
  • Detect epigenetic modifications simultaneously
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