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Axon pCLAMP 11 Software Suite

Axon pCLAMP 11 Software Suite

Patch-clamp electrophysiology data acquisition and analysis software

The pCLAMP™ Software Suite is an industry-leading patch-clamp electrophysiology data acquisition and analysis program for the control and recording of voltage-clamp, current-clamp, and patch-clamp experiments. The software suite consists of Clampex 11 Software for data acquisition, AxoScope 11 Software for background recording, Clampfit 11 Software for data analysis, and optional Clampfit Advanced Analysis Module for sophisticated and streamlined analysis.

Clampex 11 Software: flexible electrophysiology data acquisition

The focus of the Axon pCLAMP 11 Software Suite is to provide users with greater flexibility in controlling acquisition of electrophysiology data. The previous Clampex 10 version already has a powerful built-in feature set including flexible Protocol Editor, Membrane Test, P/N leak subtraction, User List and Sequencing Keys, etc. In Clampex 11, Molecular Devices have enhanced this flexibility even more with a new Protocol Editor featuring an increased number of Epochs and increased sweep duration in Episodic Stimulation acquisition mode. Gap-free mode is greatly improved with the ability to execute episodic-style Epochs and programming of digital and analog outputs. The new Membrane Test in Clampex 11 now allows viewing of multiple channels simultaneously. Independent voltage output at different stage configurations is enabled in each recorded cell. These new features provide Clampex 11 Software unparalleled ease-of-use, which makes it the software-of-choice for controlling experiments.

Comprehensive analysis tools

The software includes a wealth of analysis tools including 24 cursor pairs for regions of interest search, graph plotting tools such as I-V plot and histogram, and more.

Enhanced gap-free mode

A simple continuous ‘chart-recorder’ useful for monitoring single channel events, minis, and other spontaneous activities.  Protocol-editor-style epochs and program digital or analog outputs can be executed.

Action potential analysis*

This feature automatically detects and analyses amplitude, APD90, rise and decay time, rise and decay slope, peak-to-peak frequency and time, and more.

Improved visualization

The membrane testwindow displays up to eight channels simultaneously, making it easier to control multiple channels.

Population spike analysis*

This tool automatically calculates amplitude, area under the curve, half-width, decay and rise time, decay and rise-slope, coastline of spike, and paired pulses.

Batch analysis*

Macros for batch analysis eliminates the need to define parameters for every data set. Saves macros can be applied to multiple data sets for automatic analysis.

Enhanced Protocol Editor

Screenshot of Gap-free mode

Screenshot of Membrane Test

Screenshot of Population Spike Analysis

Clampfit 11 Software: smart data preparation and analysis

The Clampfit 11 Software offers dedicated functions to quickly prepare and analyze data. Noise can be removed from signals using highpass, lowpass, and bandpass filters with Bessel, Butterworth, Chebyshev, Gaussian, or RC responses. Specialized notch and electrical interference filters can be used to remove specific noise frequencies and harmonics from recorded signals. Several different methods are available to adjust the baselines of recordings: constant values or averages can be subtracted from all points of the recording, linear drifting baselines can be adjusted by applying a slope correction, or, for unstable baselines, a manual correction using a poly-line can be applied. Additional data analysis functions are averaging, normalization, control subtraction, and peak alignment.

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