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Multiclamp 700B Amplifier

The MultiClamp™ 700B Microelectrode Amplifier is a versatile, computer-controlled microelectrode amplifier designed for patch voltage-clamp (resistive-feedback, four ranges) or high-speed current clamp (voltage-follower, three ranges) recording within the same headstage. The system is ideal for many applications, including high-speed current clamp (sharp-electrode or field potentials), patch clamp (whole-cell, macro-patch, or excised patch), voltammetry/amperometry, ion-selective measurements and bilayer recordings.

Major new features of the MultiClamp 700B Amplifier include Internal Automatic Mode switching, triggered by external signals or the recording itself; Oscillation Suppression for better cell protection; and Slow Current Injection to compensate for drifting potentials.

  • Support of up to four headstages makes the MultiClamp 700B System four amplifiers in one.
  • Software control of all amplifier settings for automated optimization features, reduction of manipulation steps, and convenient, reliable telegraphing.
  • Quick Select Feature recalls up to three saved amplifier configurations for fast, reproducible application switching.
  • Optional SoftPanel allows amplifier control using knobs and buttons for a more conventional feel to amplifier control.
  • Integrated seal test in voltage- and current-clamp mode for easy monitoring of membrane and cell health parameters.
  • Dual Command Potentials add flexibility by processing input signals from two different sources.
  • Selectable command sensitivity for flexible control of the output waveform.
  • Pipette offset compensation with auto-mode quickly removes signal offsets.
  • Automatic pipette capacitance compensation requires only the push of a button to neutralize the contribution of the glass pipette and the pipette holder to the capacitance of the circuitry.
  • Series resistance compensation: Prediction helps achieve the desired command level faster by transiently supercharging the membrane potential.
  • Series resistance compensation: Correction improves the bandwidth of the recording by eliminating the error introduced by the voltage drop across the series resistance.
  • Automatic cell capacitance compensation corrects for the capacitance of the cell membrane in whole-cell recordings with a single mouse click.
  • Automatic mode switching enables you to control the transition between voltage and current clamp by an external trigger or depending on the recorded signal.
  • Automatic oscillation detection prevents damage to a cell when electrical feedback occurs.
  • Leak subtraction for automatic correction of leak currents with a smart, software-based algorithm.
  • Selectable output gain with 11 settings to scale the output signal to the desired level.
  • Audio monitor for acoustic tracking of the signal while you are busy looking down a microscope.
  • Fine-tunable 4-pole bessel and butterworth low-pass filters act as anti-aliasing filters and can be used to pre-condition the output signal.
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