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micro-Matrix, micro bioreactor

The micro-Matrix is a true scale down of small scale bioreactors. The bioreactor square well cassette design is based upon the popular SBS-format microtiter plates that maximize mixing, optimize gas transfer, and seamlessly integrate into lab automation protocols. PC-based ‘my-Control’ interface offers simple, intuitive interaction with each of the 24 bioreactors. Integrated LEDs indicate the status of the bioreactors (inactive / active / alarm) with color-based feedback so that operators can get instant process information with one quick glance.

Each bioreactor has its own PID controller for pH, dissolved oxygen, and temperature. Individual pH control can be achieved via gas addition, liquid addition, or a combination of both. Dissolved oxygen level can be individually controlled by up to four gas additions per bioreactor. Temperature can be individually controlled by the integrated cooling and heating system on a well-by-well basis, and users can define temperature gradients across the set of bioreactors. Each well has its individual Peltier element for cooling and heating and the complete system can be equipped with the optional cooling system to lower the temperature of the cultivation chamber.

Each of the 24 bioreactors on a plate offer independent controls like its larger stirred-tank relatives:

  • pH (measurement and two-sided control)
  • temperature (measurement and two-sided control, including plate-wide gradients)
  • dissolved oxygen control (measurement and two-sided control)
  • individual liquid additions (including feeding profiles)
  • up to 4 separate gas additions (individually controlled)

Software

The micro-Matrix software offers an easy way to operate 24 bioreactors in parallel, plus simple comparisons of large numbers of experimental cultures. Using an instinctive left-to-right progression, the interface guides operators through experimental setup, instrument configuration, control strategy definition, and data visualization. It is also possible to define time- and event-based control actions, and all data can be exported from the instrument post or during the experiment.

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micro-Matrix, micro bioreactor