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iMScope TRIO Imaging Mass Microscope

Imaging mass spectrometry is a revolutionary new technology combining an optical microscope which allows the observation of high-resolution morphological images, with a mass spectrometer which identifies and visualizes the distribution of specific molecules. Superimposing the two images obtained based on these very different principles,has created a significant new research tool, the imaging mass microscope.

Imaging mass spectrometry directly detects both natural and synthetic molecules in tissue sections and measures mass spectra, while retaining their positional information associated with the tissue section. Then, two-dimensional distributions of specific molecules are visualized by combining the positional information of each mass spectrum and the signal intensity for specific ions in the mass spectrum (MS imaging).

High Spatial Resolution

iMScope TRIO can detect a wide range of molecules within a defined mass range. Therefore, distribution information for several target molecules with different molecular weights can be determined simultaneously during a single measurement.

Pharmacokinetic Analysis

In pharmacokinetic analysis, the iMScope TRIO enables the distribution of unchanged and metabolized drugs to be simultaneously mapped in a single measurement, without any labeling. The laser diameter used during mass spectrometry imaging with the iMScope TRIO is continuously variable from 5 to 200μm, offering low to high spatial resolution. This helps ensure that analyses are performed as efficiently as possible.

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