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FLIPR Tetra High-Throughput Cellular Screening System

The FLIPR Tetra® High-Throughput Cellular Screening System is the Industry-renowned, flexible, and reliable real-time kinetic cellular assay screening system for identifying early leads against GPCR and ion channel receptors. The system is optimized for use with both fluorescence and luminescence and adapts readily to assay format with user-interchangeable 96-, 384-, and 1536-well heads.

Fast, Effective and Cellular Screening Assays

  • Configure and switch between fluorescence or luminescence read modes for assay flexibility
  • Multiple read modes support both single wavelength and ratiometric assays
  • Choice of fluorescent or dual-mode cameras (FL and LUM) for increased assay flexibility
  • Configurable pipettor height and dispense speeds ensure proper mixing without disturbing cell monolayers or non-adherent cells
  • User-configurable optics supports rapid optic changes in a multi-user, multi-assay environment
  • User-defined protocols can include up to four wash solvents to automate cleaning of cell handling system
  • 96, 384 & 1536 liquid transfer
  • User-Configurable fluidics and optics
  • Multi-wavelength kinetic reading
  • Calcium mobilization and Membrane Potential

Great Features

  • Fluorescence camera enables use of homogeneous FLIPR calcium and membrane potential kits
  • Contact based elastomeric liquid transfer for 1536 pipettor provides accurate pipetting of compounds and cells
  • Simultaneous pipet and read function enables fast kinetic assays such as calcium flux in multiple wells
  • Cell suspension system with adjustable stirring speed, pump, and pipetting parameters facilitates optimization with different cell types
  • Cell suspension system eliminates the need for separate compound plate during Aequorin assays
  • FLIPR TetraCycler Plate Handler enables microplate and pipette tip changes and facilitates integration to laboratory robotics systems
  • Software displays only options relevant to the instrument configuration and eliminates the opportunity to make protocol errors
  • User-defined protocols can include up to four wash solvents to automate cleaning of cell handling system
  • Viewing signal traces, EC50 curves, and Z factors on the fly provides quick data analysis without having to export data to another software program

Range of Assay Kits

A range of Assay Kits are offered for exploring different research areas- FLIPR Calcium Assay Kits for measuring changes of intracellular calcium in drug discovery, FLIPR Potassium Assay Kit for functional measurement of potassium channel in a cell-based assay, FLIPR Membrane Potential Assay Kits that deliver homogenous fluorescence –based formulations for observations of real-time membrane potential changes associated with ion channel activation and ion transporter proteins.

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