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cGMP Production Bioreactors

Applikon Biotechnology is the global specialist for human vaccine production systems and their bioreactors starting from Discovery to Production scale seamlessly enable optimization of the development of product to market.

Special Projects, Custom Solutions

Applikon supplies Stainless steel fermenters capacity upto 4000 ltrs meeting the GAMP and cGMP validation requirements. The bioreactors vessels are made with the highest standard SS316L material and 0.4u ra(Roughness Average) with SIP/CIP processes which can be either automatic or manual. They are fully automatic controlled using Allen Bradley or Siemens PLC control systems. All Applikon bioreactor controllers are CE approved and designed to meet the strictest electromagnetic immunity requirements to provide dependable operation.

  • Easy to clean Mirror polished external finish
  • Electro polished finished of all parts in contact with the culture (RA <0.4u)
  • Modular Design allows easy adaptation to changing process demands
  • cGMP compliant design simplifies validation
  • Compact design reduces the floor space
  • Reliable and Stable pH & DO sensors as PAT tools
  • Industry Leading BioXpert SCADA Software wtih 21CFR Part11 Compliance functions
  • Complete & Customized solutions from discovery to production
  • cGMP compliant design
  • Comprehensive Validation tools DQ FAT, IQ, OQ
  • 40+ Years of experience in building production scale fermenters

From basic physiochemical properties such as pH or dissolved oxygen to determination of biomass density or metabolite concentrations, Applikon offers several analytical technologies for making sophisticated measurements in bioprocesses. The BE2100 Biomass Monitor is a proprietary, non-invasive biomass monitoring system secured easily to the outside of a wide variety of bioreactor types; It has a wide linear range : 300 OD units! Sensor probes for oxygen, pH and carbon dioxide are designed to measure in small compartments or in very large vessels. Features include: Non-invasive sensors, Microsensors, Different measurement ranges, Sensors for liquids and gas, Calibration-free probes etc. The revolutionary BlueInOne online gas analyser combines the parallel measurement of CO2 and O2 with just one space-saving sensor.

i-Control is an easy to operate bioreactor control system and utility console. This scalable control solution is used to control processes in bioreactor systems from laboratory scale to pilot plant and production scale. The seamless scale-ability saves time and money by offering a simple scale-up of control strategy from research via pilot-plant to production. The i-Control is available in a Single, a Dual bioreactor set-up as well as in a Quad (4 bioreactors) configuration. The system is supplied pre-configured and ready to use.

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cGMP Production Bioreactors